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Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
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Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
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Frequently Asked Questions
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Research on the relationship between Vitamin D and cardiovascular disease is ongoing and presents a nuanced picture. Some studies have suggested that adequate levels of Vitamin D may be associated with a lower risk of cardiovascular events, as it plays a role in various bodily functions, including the regulation of calcium and phosphorus, which are essential for heart health. Moreover, Vitamin D's anti-inflammatory properties might contribute to improved cardiovascular health. However, the evidence is not definitive, and other studies have indicated that simply supplementing with Vitamin D may not necessarily lead to improvements in heart health outcomes.
Experts suggest that while ensuring adequate Vitamin D levels is important for overall health, it should not be viewed as a sole preventative measure for cardiovascular disease. Maintaining a balanced diet, engaging in regular physical activity, and following your healthcare provider's advice remain cornerstones for heart health. If you're concerned about your Vitamin D levels or cardiovascular health, it's a good idea to consult with a healthcare professional who can provide guidance tailored to your specific needs.
Based on user reviews, individuals taking Vitamin D3 for cardiovascular health typically report experiencing benefits within a few weeks to several months. For instance, one user noted positive effects on their cardiovascular health after just a few weeks of supplementation (Read Review). However, other users have indicated that more noticeable improvements in health and cardiovascular factors took about three months of regular intake (Read Review). Additionally, one user mentioned significant health benefits after six months of consistent use, highlighting the cumulative effects of maintaining adequate Vitamin D levels (Read Review).
In summary, while initial effects may be felt within a few weeks, it seems that a sustained period of supplementation—typically around three to six months—is necessary for more profound benefits regarding cardiovascular disease. As always, it's advisable to consult with a healthcare provider to tailor supplementation according to individual health needs and monitor progress.
Vitamin D supplementation emerges as a promising candidate for supporting cardiovascular health according to several research studies. Notably, an investigation involving 7,337 gout patients indicated that those with lower levels of 25-hydroxyvitamin D were at a higher risk for cardiovascular diseases, suggesting that maintaining adequate vitamin D levels could potentially mitigate such risks [2]. In another study focusing specifically on hypertensive patients, vitamin D supplementation resulted in significant decreases in both systolic and diastolic blood pressure, aligning with enhanced cardiovascular management strategies [4]. Overall, these findings underscore the potential importance of vitamin D in preventing cardiovascular complications.
Moreover, research exploring vitamin D's interactions with other treatments also highlights its potential role in cardiovascular health. A study combining vitamin D3 with SGLT2 inhibitors reported notable improvements in various cardio-metabolic outcomes for obese patients with sleep apnea [3]. However, it's essential to recognize that while vitamin D shows promise, further studies are crucial to fully elucidate its direct effects on cardiovascular diseases and to determine optimal supplementation strategies for different populations, such as those with chronic diseases or specific risk factors [6]. Ultimately, while the current evidence points towards a beneficial association, more extensive research could further clarify the extent of vitamin D’s impact on heart health.
Based on user reviews, many individuals have reported experiencing significant improvements in their health after starting Vitamin D3 supplementation. Commonly noted benefits include enhanced mood and energy levels, reduction in muscle pain, and a stronger immune system. For instance, one user highlighted feeling more energized and healthier after just a few weeks of use (Read Review). Others have mentioned that after three months of consistent intake, they noticed a marked decrease in the risk of cardiovascular issues and an overall boost in their emotional well-being (Read Review).
Additionally, several reviews emphasize the importance of correcting deficiencies, with one user reporting a remarkable improvement in their levels—from 17 ng/ml to 40 ng/ml—after six months of proper supplementation (Read Review). Overall, while individual results can vary, many users have expressed satisfaction with the outcomes of using Vitamin D3, particularly regarding its role in supporting cardiovascular health and improving general quality of life.
Based on user reviews, many individuals have reported positive experiences when combining Vitamin D3 with other supplements for managing cardiovascular disease. Notably, one user mentioned taking Vitamin D3 alongside vitamin K2 and omega-3 for six months, resulting in a significant improvement in their health metrics, particularly related to immunity and cardiovascular function (Read Review). Additional testimonials suggest that integrating Vitamin D with omega-3 fatty acids enhances overall wellness and cardiovascular health, particularly during periods of low sunlight exposure (Read Review).
Moreover, several users emphasized the crucial role of Vitamin D in calcium absorption and its interconnectedness with other supplements in preventing various health issues, including those related to cardiovascular disease. For instance, one review highlighted the significant health benefits experienced from taking Vitamin D in conjunction with omega-3, which appeared to support immune health and overall cardiovascular condition (Read Review). These findings suggest that the combination of Vitamin D3, omega-3, and potentially vitamin K2 can lead to a more comprehensive approach to managing cardiovascular health and enhancing overall well-being.
Based on user reviews, it appears that there is a general consensus on the importance of Vitamin D in supporting cardiovascular health, with many users recommending specific dosages. The common dosage mentioned is 2000 IU, which users report as effective for improving overall wellness and potentially reducing cardiovascular disease risk. For instance, one user expressed satisfaction with a 2000 IU dosage, noting its role in preventing issues linked to cardiovascular conditions (Read Review). Another user recommended maintaining a daily intake of 2000 IU, emphasizing its importance in maintaining cardiovascular health (Read Review).
Some users have even reported benefits from higher dosages, such as 4000 IU (Read Review) or 5000 IU (Read Review), suggesting that tailored dosages may be necessary depending on individual health conditions. However, users also advised consulting with a healthcare professional before starting any supplementation to ensure safe and effective dosing, especially considering the potential risks of excess intake (Read Review). Overall, regular monitoring of Vitamin D levels is encouraged to determine the optimal dosage for cardiovascular health.
Our findings suggested an interesting pattern. Patients with low 25(OH)D levels, specifically those below 45 nmol/L, had a higher risk of death from any cause compared to those with higher levels. In fact, those with levels of 45 nmol/L or more had about a 28% lower risk of dying from any cause. We also noted that increasing vitamin D levels above the deficiency threshold might help lower the risk of cardiovascular disease, with evidence suggesting that reaching at least 50 nmol/L is beneficial.
These results highlight the importance of maintaining adequate vitamin D levels for gout patients, as it appears to be linked to reduced mortality risk, particularly related to cardiovascular issues. This study adds to the growing conversation about vitamin D's role in heart health and suggest we may need to consider vitamin D supplementation in patient care strategies.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
References
- Vanreusel I, Hens W, Van Craenenbroeck EM, Paelinck BP, Segers VFM, et al. Vitamin D levels correlate with exercise capacity in adults with CHD. Cardiol Young. 2025. doi:10.1017/S1047951125000526
- Fang X, Zhang J, Zhang Z, Ye D. Association between Vitamin D and mortality risk in gout patients. J Public Health (Oxf). 2025. doi:10.1093/pubmed/fdaf010
- Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. doi:10.1186/s12967-025-06312-w
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x
- Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. doi:10.1186/s12882-025-04041-2
- Liu C, Wongsonegoro H, Sheng T, Fan H, Zhang J. Associations between serum micronutrients and all-cause, cancer, and cardiovascular mortality in a national representative population: Mediated by inflammatory biomarkers. Redox Biol. 2025;81:103573. doi:10.1016/j.redox.2025.103573
- Zhang N, Wang Y, Li W, Wang Y, Zhang H, et al. Association between serum vitamin D level and cardiovascular disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Sci Rep. 2025;15:6454. doi:10.1038/s41598-025-90785-8
- Zhang X, Liu J, Han L, Luo G, Jiang P, et al. Vitamin D reduces VSMC foam cell formation and protects against AS progression. J Endocrinol. 2025;265. doi:10.1530/JOE-24-0056
- Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. doi:10.30476/ijms.2024.101112.3372
- Bulfone L, Vacca A, Brosolo G, Da Porto A, Bertin N, et al. Subclinical Carotid Disease Is Associated with Low Serum Vitamin D in Nondiabetic Middle-Aged Hypertensive Patients. Nutrients. 2025;17. doi:10.3390/nu17030480
- Li Q, Tong Y, Guo J, Liang X, Shao H, et al. Vitamin D Receptor Regulates Oxidative Stress and Apoptosis Via the HIF-1α/HO-1 Pathway in Cardiomyocytes. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01681-x
- Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. doi:10.1186/s12882-025-04041-2
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. doi:10.1007/s11033-024-10168-6
- Qi RQ, Chen YF, Cheng J, Song JW, Chen YH, et al. Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling. Mol Med. 2024;30:223. doi:10.1186/s10020-024-00997-3
- France-Ratcliffe M, Harrison SL, Verma LA, Abdul-Rahim AH, McCallum L, et al. Vitamin D and cardiovascular outcomes in multiple sclerosis. Mult Scler Relat Disord. 2024;92:106155. doi:10.1016/j.msard.2024.106155
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. doi:10.4103/abr.abr_380_23
- Pan YX, Fu YC, Chen H, Zhao MY. [Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:1388. doi:10.3760/cma.j.cn112150-20240519-00403
